Katalin Monostory , Sándor Paku , Balázs Sarkadi , Gergely Szakács and András

ABCC6 is a basolateral plasma membrane protein.

RATIONALE ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy. To elucidate the role of ABCC6 in cellular physiology and disease, it is crucial to establish the exact subcellular localization of the native ABCC6 protein. OBJECTIVE In a recent article in Circulation Research, ABCC6 was reported ...

Correction: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study

Reference 1. Tõkés A-M, Kulka J, Paku S, Szik A, Páska C, Novák PK, Szilák L, Kiss A, Bögi K, Schaff Z: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 2005, 7:R296-R305. Correction Correction: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study Anna-Mária Tõkés1,...

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

In drug discovery, prediction of selectivity and toxicity require the evaluation of cellular calcium homeostasis. The rat is a preferred laboratory animal for pharmacology and toxicology studies, while currently no calcium indicator protein expressing rat model is available. We established a transgenic rat strain stably expressing the GCaMP2 fluorescent calcium sensor by a transposon-based meth...

The characterization of the subcellular localization and function of the human ABCB6 protein

Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.

In this review we give an overview of the physiological functions of a group of ATP binding cassette (ABC) transporter proteins, which were discovered, and still referred to, as multidrug resistance (MDR) transporters. Although they indeed play an important role in cancer drug resistance, their major physiological function is to provide general protection against hydrophobic xenobiotics. With a...